Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies
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Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies
Metallothioneins (MTs) are proteins that function by metal exchange to regulate the bioavailability of metals, such as zinc and copper. Copper functions in the brain to regulate mitochondria, neurotransmitter production, and cell signaling. Inappropriate copper binding can result in loss of protein function and Cu(I)/(II) redox cycling can generate reactive oxygen species. Copper accumulates in...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2017
ISSN: 1662-453X
DOI: 10.3389/fnins.2017.00114